STRI logo images

STRI logo images

Stem Cell Treatment & Research Institution

Diabetes.

Our goal is to cure the diabetes using differentiated beta cell from nEPS.
STRI research team conducts experiment with cell pouch composed of nEPS cells and beta cells
The nEPS and nEPS differentiated beta cells can improve glucose level in diabetes.

What we have achieved so far:

– STRI has studied type I diabetes (STZ-induced diabetic mouse) with nEPS transplant to regulate glucose levels with 426 follow-up days.
– Transplanted nEPS group regenerated pancreatic beta-cell islet.
– STRI has studied type II diabetes (db/db mouse) with nEPS injection to check the decrease of glucose level.

Diabetes Program

Diabetes mellitus has no permanent cure to date. One of the plausible therapeutic strategies to achieve this goal is through pancreatic stem cell transplantation. Various stem cell sources and manipulation techniques can be used to generate functional β-cells safely and efficiently. And in this respect, we believe nEPS cell technology possesses the potential of becoming an alternative strategy for generating insulin-producing cells in a relatively harmless and practical way. We proved the generation of functional pancreatic β-cells in both in vitro or in vivo studies.
We successfully developed a highly efficient differentiation protocol for human pluripotent stem cell differentiation that yielded functionally β-cells resembling those of adult human pancreatic β-cells. It demonstrated the expression of insulin gene and protein in vitro.

Intravenous Cell Injections:

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The transplanted nEPS-derived β-cells were able to survive within the tissue environment where they were engrafted. Moreover, preliminary data from a small cohort of diabetes mellitus mouse model (STZ-induced diabetic mouse) also demonstrated a promising result in which correction of hyperglycemia as glucose level decrease following IV (intravenous) transplantation of nEPS-derived β-cells.

Transplantation of Cell Pouch:

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Cell pouch contains pancreatic β-cells differentiated nEPSs that its proprietary structure releases insulin into the blood vessel and optimizes cell survival with oxygen and nutrient supply from the blood vessel.

The utilization of the cell pouch is its easiness to formulate blood vessels between lattice structure. These vessels are also able to prevent the attack of immune cells.

Its spheroid formation of pancreatic β-cells improves the survival rate of the cell and increases effectiveness of insulin secretion.

Confirmed the effect of blood glucose regulation on diabetes:

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Collaboration Research with Surgery and Pathology of Bundang Seoul National University Hospital